Increasing batch-to-batch reproducibility of CHO cultures by robust open-loop control
نویسندگان
چکیده
منابع مشابه
Robust Control with Youla Parametrization of Yeast Fed-batch Cultures
Optimal productivity of S. cerevisiae cultures can be achieved through the regulation of the ethanol concentration at a low value. In this study, a robust control strategy is developed, which requires very little knowledge about the process, i.e. only one yield coefficient and the on-line measurement of the ethanol concentration. A Youla parametrization is selected in order to reject asymptotic...
متن کاملRobust adaptive control of yeast fed-batch cultures
A robust controller combining a feedforward compensator (for the measured disturbance) and a feedback RST controller is designed for the control of S. cerevisiae cultures. The controller is based on the linearization of Sonnleitner’s model allowing a simple transfer function model to be derived, which describes the relation between the ethanol concentration, the substrate feed and a measurable ...
متن کاملOpen-loop and closed-loop robust optimal control of batch processes using distributional and worst-case analysis
The recognition that optimal control trajectories for batch processes can be highly sensitive to model uncertainties has motivated the development of methods for explicitly addressing robustness during batch processes. This study explores the incorporation of robust performance analysis into open-loop and closed-loop optimal control design. Several types of robust performance objectives are inv...
متن کاملRobust identification and control of batch processes
An approach is proposed for the robust identification and control of batch and semibatch processes. The batch experiments used for model identification are designed by minimizing the magnitude of the parameter uncertainties, and the effect of these uncertainties on the product quality achievable by optimal control is used as a stopping criterion for the identification procedure. The optimal con...
متن کاملA Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media
CHO cell culture high productivity relies on optimized culture medium management under fed-batch or perfused chemostat strategies enabling high cell densities. In this work, a dynamic metabolic model for CHO cells was further developed, calibrated and challenged using datasets obtained under four different culture conditions, including two batch and two fed-batch cultures comparing two differen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cytotechnology
سال: 2010
ISSN: 0920-9069,1573-0778
DOI: 10.1007/s10616-010-9320-y